Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis
نویسندگان
چکیده
منابع مشابه
I]FP-CIT SPECT images
Aim The purpose of the current paper is to present a computational solution to accurately quantify a specific to a non-specific uptake ratio in [ 123 I]FP-CIT single photon emission computed tomography (SPECT) images and simultaneously measure the spatial dimensions of the basal ganglia, commonly known as basal nuclei. A statistical analysis based on a reference dataset selected by the user is ...
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Objectives: To examine the validity of [I]β-CIT SPECT for monitoring the progression of dopaminergic degeneration in Parkinson’s disease; to investigate the influence of short term treatment with D2 receptor agonists on striatal [I]β-CIT binding; and to determine the sample size and frequency of SPECT imaging required to demonstrate a significant effect of a putative neuroprotective agent. Meth...
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Dopamine transporter (DAT) imaging using single-photon emission computed tomography (SPECT) and (123)I-labelled radiopharmaceuticals like [(123)I]FP-CIT is an established part in the diagnostic work-up of parkinsonism. Guidelines recommend attenuation correction (AC), either by a calculated uniform attenuation matrix (calAC) or by a measured attenuation map (nowadays done by low-dose CT; CTAC)....
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its differentiation from Alzheimer’s disease, is important for optimum management, including provision of appropriate information to patients and carers, initiation of effective treatments and avoidance of potentially life-threatening antipsychotic drugs. Consensus clinical diagnostic criteria have high specificity for diagnosis of probable dementia with Lewy bodies but poor sensitivity; data f...
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Correspondence to Françoise J Siepel; [email protected] ABSTRACT Objectives: Little is known regarding the ‘falsenegative’ or ‘false-positive’ striatal dopamine transporter binding on SPECT for the diagnosis of dementia with Lewy bodies (DLB). We explored the clinical course in patients fulfilling the criteria for clinical DLB with a normal (I)FP-CIT SPECT (ie, SPECT scan negative, clinical feature...
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ژورنال
عنوان ژورنال: Annals of Nuclear Medicine
سال: 2018
ISSN: 0914-7187,1864-6433
DOI: 10.1007/s12149-018-1297-1